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F-Actin (Smooth Muscle) Antibody, IgG by ELISA with Reflex to Smooth Muscle Antibody, IgG Titer
Ordering Recommendation
May be helpful in evaluating for autoimmune liver disease. For a more comprehensive reflex panel, refer to Autoimmune Liver Disease Reflexive Panel (3002479).
New York DOH Approval Status
Specimen Required
Serum Separator Tube (SST).
Separate from cells ASAP or within 2 hours of collection. Transfer 1 mL serum to an ARUP Standard Transport Tube.(Min: 0.25 mL)
Refrigerated.
Plasma. Contaminated, heat-inactivated, hemolyzed, or lipemic specimens.
After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year
Methodology
Semi-Quantitative Enzyme-Linked Immunosorbent Assay/Semi-Quantitative Indirect Fluorescent Antibody
Performed
Sun-Sat
Reported
1-5 days
Reference Interval
| Test Number |
Components |
Reference Interval |
|---|---|---|
| F-Actin (Smooth Muscle) Ab, IgG by ELISA | 19 Units or less |
Interpretive Data
| F-Actin (Smooth Muscle) Antibody, IgG | Interpretive Data |
|---|---|
| 19 Units or less | Negative |
| 20-30 Units | Weak Positive - Suggest repeat testing in two or three weeks with a fresh specimen. |
| 31 Units or greater | Positive - Suggestive of autoimmune hepatitis or chronic active hepatitis. |
FDA
Note
In viral hepatitis the titers are generally less than 1:80 and are transient. The titers in primary biliary cirrhosis are also low, ranging from 1:20 to 1:40.
If F-Actin is 20 Units or greater, then Smooth Muscle Ab, IgG IFA titer will be added. Additional charges apply
Hotline History
CPT Codes
86015; if reflexed, add 86256
Components
| Component Test Code* | Component Chart Name | LOINC |
|---|---|---|
| 0055248 | F-Actin (Smooth Muscle) Ab, IgG by ELISA | 44706-0 |
Aliases
- Actin Antibody
- Actin Antibody Reflexive Panel
- Anti-Smooth Muscle Antibody
- ASMA
- ASMA Reflexive Panel
- F-Actin Antibody
- F-Actin Antibody Panel
- SMA
- SMA IgG
- SMA IgG Ab
- SMA Reflexive Panel
- Smooth Muscle Antibodies
- Soft-SMA
